Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect
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چکیده
منابع مشابه
Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect.
We have previously reported an increased expression of cytokeratins 8/18 (K8/K18) in cells expressing the F508del mutation of cystic fibrosis transmembrane conductance regulator (CFTR). This is associated with increased colocalization of CFTR and K18 in the vicinity of the endoplasmic reticulum, although this is reversed by treating cells with curcumin, resulting in the rescue of F508del-CFTR. ...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2011
ISSN: 1460-2083,0964-6906
DOI: 10.1093/hmg/ddr496